2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel
  5. P/Q-type calcium channel Isoform

P/Q-type calcium channel

P/Q-type calcium channels (CaV2.1) are high-voltage-gated calcium channels that contribute to vesicle release at synaptic terminals and primarily support synaptic transmission at fast synapses[1][2]. Mechanistically, depolarization activates presynaptic Ca2+ channels, Ca2+ entry triggers neurotransmitter release, and CaV2.1 forms active-zone signaling complexes that regulate synaptic strength and presynaptic plasticity[3]. In disease-relevant models, CaV2.1 dysfunction or mutation links this channel to ataxia, migraine, Alzheimer’s disease, episodic ataxia type 2, familial hemiplegic migraine type 1, and spinocerebellar ataxia type 6[1][4]. Compared with related isoforms, CaV2 channels initiate fast synaptic transmission, whereas CaV1 channels support contraction, secretion, gene-expression regulation, synaptic-input integration, and ribbon-synapse transmission, and CaV3 channels support repetitive firing in rhythmically firing cells[2]. Experimental studies also distinguish P/Q-type channels from N-type channels because P/Q-preferring presynaptic slots can accept N-type channels, whereas overexpressed P/Q-type channels do not reciprocally replace N-type channels[5]. For experimental applications, ω-agatoxins remain the only specific P/Q-type blockers, while other peptide blockers and low-molecular-weight compounds show lower selectivity or complex modulation profiles[1][6].

P/Q-type calcium channel Related Products (6):

Cat. No. Product Name Effect Purity
  • HY-P1080A
    ω-Agatoxin IVA TFA
    		Inhibitor 99.52%
    ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA TFA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA TFA can be used for the research of neurological and cardiovascular disease.
  • HY-12498
    GV-58
    		Agonist 99.22%
    GV-58 is a novel N- and P/Q-type calcium (Ca2+) channel agonist with EC50s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca2+ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research.
  • HY-P1080
    ω-Agatoxin IVA
    		Inhibitor 98.71%
    ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50 values of 2 nM and 90 nM. ω-Agatoxin IVA inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA inhibits Capsaicin (HY-10448)-induced CGRP release and vasodilation. ω-Agatoxin IVA can be used for the research of neurological and cardiovascular disease.
  • HY-P1079
    ω-Agatoxin TK
    		Inhibitor ≥99.0%
    ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels.
  • HY-131942
    sFTX-3.3
    		Antagonist
    sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.
  • HY-135478
    LY393615
    		Inhibitor
    LY393615 (NCC1048) is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.